Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
20/08/2021 |
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Data da última atualização: |
15/09/2021 |
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Tipo da produção científica: |
Nota Técnica/Nota Científica |
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Autoria: |
OTTO, P. I.; GUIMARAES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; SEVILLANO, C. A.; PRATA, M. C. de A.; FURLONG, J.; FREITAS, C. de; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GARCIA, A. O.; DAIBERT, R. M. de P.; SILVA, M. V. G. B.; MACHADO, M. A. |
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Afiliação: |
PAMELA I. OTTO, Universidade Federal de Viçosa; SIMONE E. F. GUIMARAES, Universidade Federal de Viçosa; LUCAS L. VERARDO, Universidade Federal de Viçosa; ANA LUISA SOUSA AZEVEDO, CNPGL; CLAUDIA A. SEVILLANO, Topigs Norsvin Research Center; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; JOHN FURLONG; CELIO DE FREITAS, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARTA FONSECA MARTINS, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; ARIELLY O. GARCIA, Universidade Federal de Viçosa; RAQUEL M. DE PAIVA DAIBERT, Universidade Federal de Juiz de Fora; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MARCO ANTONIO MACHADO, CNPGL. |
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Título: |
Genome wide association study for gastrointestinal nematodes resistance in Bos taurus x Bos indicus crossbred cattle. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Livestock Science, v. 245, 104403, 2021. |
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DOI: |
https://doi.org/10.1016/j.livsci.2021.104403 |
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Idioma: |
Inglês |
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Notas: |
Short communication. |
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Conteúdo: |
Gastrointestinal nematodes (GIN) parasitism is a very important problem on livestock production, especially in cattle, where the infections are usually subclinical making difficult the diagnosis and aggravating the losses caused by these parasites. This study aimed to identify genomic regions associated with nematode fecal egg count (FEC) in a Gir x Holstein F2 experimental population and to identify candidate genes within the quantitative trait loci (QTL) regions. The FEC phenotypes were evaluated in F2 animals during dry and rainy seasons. Illumina BovineSNP50 BeadChip was used to genotype the animals for single-SNP genome wide association studies. Three significant SNPs on chromosome 15 were found to be associated with FEC. From the QTL regions containing the SNPs, one functional candidate gene was identified: the myogenic differentiation 1 (MYOD1) gene, which plays an important role in the myogenesis and muscle repair. Further studies are needed to refine the QTL region identified here and to pursue additional SNPs associated to FEC trait in the Gir x Holstein genome, as well as to deeply investigate and validate the effect of this functional candidate gene. |
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Palavras-Chave: |
Post-GWAS analyses. |
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Thesagro: |
Bovino; Gado Mestiço; Helminto; Infecção. |
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Thesaurus NAL: |
Endoparasites; Helminths; Infection. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02403naa a2200421 a 4500
001 2133782
005 2021-09-15
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.livsci.2021.104403$2DOI
100 1 $aOTTO, P. I.
245 $aGenome wide association study for gastrointestinal nematodes resistance in Bos taurus x Bos indicus crossbred cattle.$h[electronic resource]
260 $c2021
500 $aShort communication.
520 $aGastrointestinal nematodes (GIN) parasitism is a very important problem on livestock production, especially in cattle, where the infections are usually subclinical making difficult the diagnosis and aggravating the losses caused by these parasites. This study aimed to identify genomic regions associated with nematode fecal egg count (FEC) in a Gir x Holstein F2 experimental population and to identify candidate genes within the quantitative trait loci (QTL) regions. The FEC phenotypes were evaluated in F2 animals during dry and rainy seasons. Illumina BovineSNP50 BeadChip was used to genotype the animals for single-SNP genome wide association studies. Three significant SNPs on chromosome 15 were found to be associated with FEC. From the QTL regions containing the SNPs, one functional candidate gene was identified: the myogenic differentiation 1 (MYOD1) gene, which plays an important role in the myogenesis and muscle repair. Further studies are needed to refine the QTL region identified here and to pursue additional SNPs associated to FEC trait in the Gir x Holstein genome, as well as to deeply investigate and validate the effect of this functional candidate gene.
650 $aEndoparasites
650 $aHelminths
650 $aInfection
650 $aBovino
650 $aGado Mestiço
650 $aHelminto
650 $aInfecção
653 $aPost-GWAS analyses
700 1 $aGUIMARAES, S. E. F.
700 1 $aVERARDO, L. L.
700 1 $aAZEVEDO, A. L. S.
700 1 $aSEVILLANO, C. A.
700 1 $aPRATA, M. C. de A.
700 1 $aFURLONG, J.
700 1 $aFREITAS, C. de
700 1 $aVERNEQUE, R. da S.
700 1 $aMARTINS, M. F.
700 1 $aPANETTO, J. C. do C.
700 1 $aCARVALHO, W. A.
700 1 $aGARCIA, A. O.
700 1 $aDAIBERT, R. M. de P.
700 1 $aSILVA, M. V. G. B.
700 1 $aMACHADO, M. A.
773 $tLivestock Science$gv. 245, 104403, 2021.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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